Coronory Artery Disease (CAD)
• Symptomatic treatment of chronic stable angina pectoris in coronary artery disease adults with normal sinus rhythm:
• Who are unable to tolerate or have a contraindication to beta blockers, or
• In combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose and whose heart rate is > 60 bpm.

Chronic Heart Failure (CHF)
• Symptomatic treatment of chronic heart failure of NYHA Classes II or III and with documented left ventricular ejection fraction (LVEF) ≤ 35% in adult patients in sinus rhythm and with heart rate at or above 77 bpm, in combination with optimal standard chronic heart failure treatment.