Zoldap (Linezolid) is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below. Zoldap (Linezolid) is not indicated for the treatment of Gram-negative infections. It is critical that specific Gram-negative therapy be initiated immediately if a concomitant Gram-negative pathogen is documented or suspected.

Pneumonia

• Nosocomial pneumonia caused by Staphylococcus aureus (methicillin-susceptible and resistant isolates) or Streptococcus pneumoniae.
• Community-acquired pneumonia caused by Streptococcus pneumoniae, including cases with concurrent bacteremia or Staphylococcus aureus (methicillin-susceptible isolates).

Skin and Skin Structure Infections

• Complicated skin and skin structure infections, including diabetic foot infections, without concomitant osteomyelitis caused by Staphylococcus aureus (methicillin-susceptible and resistant isolates), Streptococcus pyogenes or Streptococcus agalactiae.
• Uncomplicated skin and skin structure infections caused by Staphylococcus aureus (methicillin-susceptible isolates only) or Streptococcus pyogenes.

Vancomycin-resistant Enterococcus faecium Infections

• Vancomycin-resistant Enterococcus faecium infections, including cases with concurrent bacteremia.